While the 49ers aren't particularly overpowering, they have an offense that features a unique backfield that can eat up yards in a variety of ways.
Let’s talk about Jimmy Garoppolo. He’s a pure pocket passer with plenty of Throw Power. His accuracy numbers have a steep drop-off beyond short range, so throw with caution.
Fortunately, the Niners have some WRs that specialize in shorter routes. Pierre Garcon is extremely reliable with great Catch scores. Marquise Goodwin is insanely fast. Garoppolo might not have the accuracy to hit Goodwin deep too often, but look to his Speed to make a difference after cuts, like in post or in routes.
HBs Jerick McKinnon and Matt Breida along with FB Kyle Juszczyk make up a talented and rare backfield. McKinnon and Breida are fairly fast while Juszczyk is an excellent power option. They can all catch well enough, but Juszczyk himself has better Catch and Route Running ratings, creating a unique mismatch on coverage.
Richard Sherman is the big acquisition for the Niners defense. Still one of the best CBs around, it’s a dangerous proposition to throw in his direction. He’s great in zone and 1v1, but he could have issues with speedsters. Great User Lurk potential.
SS Jaquiski Tartt is the big hitter coming out of the secondary. Tartt is significantly better in zone, so you may want to control him in man coverage schemes to prevent giving up big plays.
The D-line in San Francisco has some potential, led by the beasty DeForest Buckner. Better on the attack than most defensive tackles, Buckner has enough Hit Power to force a fumble once he’s through the line.